Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 + T cells-Reference-Cited by-同舟云学术

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 + T cells

Published:2020-07-03 Issue:27 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Rath Jan A.¹^ORCID,Bajwa Gagan²^ORCID,Carreres Benoit¹^ORCID,Hoyer Elisabeth²,Gruber Isabelle¹^ORCID,Martínez-Paniagua Melisa A.³^ORCID,Yu Yi-Ru¹^ORCID,Nouraee Nazila²^ORCID,Sadeghi Fatemeh³,Wu Mengfen⁴,Wang Tao⁴,Hebeisen Michael¹,Rufer Nathalie¹,Varadarajan Navin³^ORCID,Ho Ping-Chih¹^ORCID,Brenner Malcolm K.²⁵⁶⁷^ORCID,Gfeller David¹^ORCID,Arber Caroline¹²⁵^ORCID

Affiliation:

1. Department of Oncology UNIL-CHUV, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.

2. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children’s Hospital, Houston, TX, USA.

3. Department of Chemical and Biomolecular Engineering, University of Houston, TX, USA.

4. Biostatistics Shared Resource, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.

5. Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

6. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

7. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Abstract

TCR-CD8–engineered CD4 + T cells have potent antitumor activity with sustained expression of diverse transcriptional programs.

Funder

National Institutes of Health

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Leukemia and Lymphoma Society

Swiss National Science Foundation

Swiss Government Excellence Scholarship

Krebsforschung Schweiz

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection

2. Generation of T Cell Help through a MHC Class I-Restricted TCR

3. Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase

4. Human MHC Class I-restricted high avidity CD4+T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

5. Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4+ T Cells

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