Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans

Author:

Galarza Vallejo Ana1ORCID,Kroes Marijn C. W.123ORCID,Rey Enrique4ORCID,Acedo Maria Victoria5,Moratti Stephan16,Fernández Guillén3ORCID,Strange Bryan A.17ORCID

Affiliation:

1. Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain.

2. Department of Psychology and Center for Neural Science, New York University, New York, NY, USA.

3. Donders Institute for Brain, Cognition, and Behaviour, Donders Institute, Radboud University Medical Centre, Nijmegen 6525 EZ, Netherlands.

4. Department of Gastroenterology, Hospital Clínico San Carlos and Instituto de Investigación Sanitaria San Carlos, Universidad Complutense de Madrid, Spain.

5. Department of Anesthesia, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos, Universidad Complutense de Madrid, Spain.

6. Department of Basic Psychology I, Complutense University of Madrid, Spain.

7. Department of Neuroimaging, Alzheimer’s Disease Research Centre, Reina Sofia–CIEN Foundation, Madrid, Spain.

Abstract

Administering the anesthetic propofol after a brief reminder reduces retrieval of established emotional memory 24 hours later.

Funder

H2020 Marie SkÅ?odowska-Curie Actions

FP7 People: Marie-Curie Actions

Ministerio de Economía y Competitividad

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference57 articles.

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3. Neurobiology of anxiety disorders and implications for treatment;Garakani A.;Mt. Sinai J. Med.,2006

4. Memory mechanisms in posttraumatic stress disorder;Layton B.;J. Neuropsychiatry Clin. Neurosci.,2002

5. A memory-based model of posttraumatic stress disorder: Evaluating basic assumptions underlying the PTSD diagnosis;Rubin D. C.;Psychol. Rev.,2008

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