Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

Author:

Zafferani Martina1ORCID,Haddad Christina2ORCID,Luo Le2ORCID,Davila-Calderon Jesse2ORCID,Chiu Liang-Yuan2ORCID,Mugisha Christian Shema3ORCID,Monaghan Adeline G.1,Kennedy Andrew A.4ORCID,Yesselman Joseph D.5,Gifford Robert J.6ORCID,Tai Andrew W.4ORCID,Kutluay Sebla B.3ORCID,Li Mei-Ling7ORCID,Brewer Gary7ORCID,Tolbert Blanton S.2ORCID,Hargrove Amanda E.1ORCID

Affiliation:

1. Chemistry Department, Duke University, 124 Science Drive, Durham, NC 27705, USA.

2. Department of Chemistry, Case Western Reserve University, Cleveland, OH 441106, USA.

3. Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

4. Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan, 1150 W Medical Center Dr., Ann Arbor, MI 48109, USA.

5. Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

6. MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Rd., Bearsden, Glasgow G61 1QH, UK.

7. Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.

Abstract

Small-molecule targeting of RNA stem loops in 5′-end of SARS-CoV-2 reveals novel RNA targets for viral inhibition.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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