Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells

Author:

Wei Xiangxiang1ORCID,Guo Jieyu1ORCID,Li Qinhan1,Jia Qianqian2,Jing Qing2ORCID,Li Yan3ORCID,Zhou Bin3ORCID,Chen Jiayu4,Gao Shaorong4,Zhang Xinyue1ORCID,Jia Mengping1,Niu Cong1,Yang Wenlong5,Zhi Xiuling1,Wang Xinhong1,Yu Dian1,Bai Lufeng6ORCID,Wang Lin6ORCID,Na Jie6ORCID,Zou Yunzeng5,Zhang Jianyi7ORCID,Zhang Shuning5ORCID,Meng Dan1ORCID

Affiliation:

1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

2. CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

3. The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

4. Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

5. Department of Cardiology, Zhongshan Hospital, Shanghai Cardiovascular Medical Center, Shanghai Institute of Cardiovascular Diseases, Institute of Pan-vascular Medicine, Fudan University, Shanghai 200032, China.

6. Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.

7. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Abstract

Bach1 is a key determinant of pluripotency, self-renewal, and cell fate determination in human embryonic stem cells.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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