Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle

Author:

Gabriel Brendan M.12ORCID,Altıntaş Ali3ORCID,Smith Jonathon A. B.1ORCID,Sardon-Puig Laura4,Zhang Xiping5ORCID,Basse Astrid L.3ORCID,Laker Rhianna C.3ORCID,Gao Hui6ORCID,Liu Zhengye7ORCID,Dollet Lucile1,Treebak Jonas T.3ORCID,Zorzano Antonio8910ORCID,Huo Zhiguang11ORCID,Rydén Mikael12ORCID,Lanner Johanna T.7ORCID,Esser Karyn A.5ORCID,Barrès Romain3ORCID,Pillon Nicolas J.1ORCID,Krook Anna1ORCID,Zierath Juleen R.134ORCID

Affiliation:

1. Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

2. Aberdeen Cardiovascular and Diabetes Centre, The Rowett Institute, University of Aberdeen, Aberdeen, UK.

3. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

4. Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

5. Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.

6. Department of Biosciences and Nutrition (BioNut), Karolinska Institutet, Stockholm, Sweden.

7. Department of Physiology and Pharmacology, Molecular Muscle Physiology and Pathophysiology, Karolinska Institutet, Stockholm, Sweden.

8. Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.

9. Departament de Bioquímica y Biomedicina Molecular, Facultat de Biologia, Barcelona, Spain.

10. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Spain.

11. Department of Biostatistics, University of Florida, Gainesville, FL, USA.

12. Department of Medicine (H7), Unit for Endocrinology and Diabetes, Karolinska Institutet, Stockholm, Sweden.

Abstract

Disturbances in daily rhythms of mitochondrial activity may contribute to skeletal muscle insulin resistance in type 2 diabetes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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