Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import-Reference-Cited by-同舟云学术

Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import

Published:2019-10-04 Issue:10 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Li Junhua¹^ORCID,Zhao Jun¹,Xu Simin¹^ORCID,Zhang Shu¹^ORCID,Zhang Junjie¹^ORCID,Xiao Jun¹²,Gao Ruoyun¹,Tian Mao¹,Zeng Yi¹³,Lee Katie¹,Tarakanova Vera⁴,Lan Ke⁵^ORCID,Feng Hao²,Feng Pinghui¹^ORCID

Affiliation:

1. Section of Infection and Immunity, Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.

2. Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.

3. Department of Pathology and Immunology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China.

4. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

5. State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei 430072, P.R. China.

Abstract

A nucleotide metabolic enzyme restricts viral lytic replication via protein deamidation.

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institute of Dental and Craniofacial Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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