Apolipoprotein- ε 4 is associated with higher fecundity in a natural fertility population

Author:

Trumble Benjamin C.12ORCID,Charifson Mia3ORCID,Kraft Tom4ORCID,Garcia Angela R.256,Cummings Daniel K.7ORCID,Hooper Paul7ORCID,Lea Amanda J.89ORCID,Eid Rodriguez Daniel10ORCID,Koebele Stephanie V.2ORCID,Buetow Kenneth211,Beheim Bret12ORCID,Minocher Riana12ORCID,Gutierrez Maguin13,Thomas Gregory S.1415,Gatz Margaret16ORCID,Stieglitz Jonathan17ORCID,Finch Caleb E.18ORCID,Kaplan Hillard7ORCID,Gurven Michael19ORCID

Affiliation:

1. School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA.

2. Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.

3. Department of Population Health, New York University Grossman School of Medicine, New York City, NY, USA.

4. Anthropology Department, University of Utah, Salt Lake City, UT, USA.

5. Scientific Research Core, Phoenix Children's Hospital, Phoenix, AZ, USA.

6. Department of Child Health, University of Arizona, Tucson, AZ, USA.

7. Department of Health Economics and Anthropology, Economic Science Institute, Argyros School of Business and Economics, Chapman University, Orange, CA, USA.

8. Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

9. Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.

10. Universidad de San Simon, Cochabamba, Bolivia.

11. School of Life Sciences, Arizona State University, Tempe, AZ, USA.

12. Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

13. Tsimane Gran Consejo, San Borja, Bolivia.

14. MemorialCare Health System, Fountain Valley, CA, USA.

15. University of California, Irvine, CA, USA.

16. Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.

17. Institute for Advanced Study in Toulouse, Université Toulouse 1 Capitole, Toulouse, France.

18. Leonard Davis School of Gerontology and Dornsife College, University of Southern California, Los Angeles, CA, USA.

19. Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA.

Abstract

In many populations, the a polipoprotein- ε 4 ( APOE- ε 4 ) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE- ε 4 allele remains prevalent. We assess the impact of APOE- ε 4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20% APOE- ε 4 carriers), those with at least one APOE- ε 4 allele had 0.3 to 0.5 more children than (ε3/ε3) homozygotes, while those with two APOE- ε 4 alleles gave birth to 1.4 to 2.1 more children. APOE- ε 4 carriers achieve higher fertility by beginning reproduction 0.8 years earlier and having a 0.23-year shorter interbirth interval. Our findings add to a growing body of literature suggesting a need for studies of populations living in ancestrally relevant environments to assess how alleles that are deleterious in sedentary urban environments may have been maintained by selection throughout human evolutionary history.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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