Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

Author:

Liang Jingjing1ORCID,Wang Huifang2ORCID,Ding Wenxiu3ORCID,Huang Jianxiang2ORCID,Zhou Xuefei2ORCID,Wang Huiyang3ORCID,Dong Xue1ORCID,Li Guangyao1ORCID,Chen Enguo4ORCID,Zhou Fei1ORCID,Fan Hongjie1ORCID,Xia Jingya1ORCID,Shen Bo1ORCID,Cai Da1ORCID,Lan Pengxun1ORCID,Jiang Hanliang5ORCID,Ling Jun6ORCID,Cheng Zhen7ORCID,Liu Xiangrui12ORCID,Sun Jihong1ORCID

Affiliation:

1. Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

2. Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

3. Second Clinical Medical College, Zhejiang Chinese Medical University, Quzhou 310053, China.

4. Department of Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

5. Pulmonary and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

6. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

7. Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Stanford University Medical Center, Stanford, CA 94305, USA.

Abstract

Stimuli-responsive nano-immunochemotherapy modulates the tumor microenvironment to enhance antitumor immunity.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China Stem Cell and Translational Research

Key research and development program of Zhejiang province

National Postdoctoral Science Foundation of China Grants

Zhejiang Postdoctoral Selective Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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