Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine

Author:

Yeola Avani12ORCID,Subramanian Shruthi13ORCID,Oliver Rema A.4ORCID,Lucas Christine A.5,Thoms Julie A. I.12ORCID,Yan Feng6ORCID,Olivier Jake7ORCID,Chacon Diego8,Tursky Melinda L.9,Srivastava Pallavi10ORCID,Potas Jason R.11ORCID,Hung Tzongtyng12ORCID,Power Carl12,Hardy Philip13,Ma David D.9,Kilian Kristopher A.10ORCID,McCarroll Joshua14ORCID,Kavallaris Maria141516ORCID,Hesson Luke B.317,Beck Dominik8,Curtis David J.618ORCID,Wong Jason W. H.19,Hardeman Edna C.5ORCID,Walsh William R.4ORCID,Mobbs Ralph420,Chandrakanthan Vashe12ORCID,Pimanda John E.12321ORCID

Affiliation:

1. Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.

2. School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

3. Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

4. Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.

5. Cellular and Genetic Medicine Unit, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.

6. Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.

7. School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW 2052, Australia.

8. School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.

9. St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.

10. School of Material Sciences and Engineering, School of Chemistry, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.

11. Translational Neuroscience Facility, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.

12. Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW 2052, Australia.

13. Cyto Labs, Bentley, WA 6102, Australia.

14. Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia.

15. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.

16. School of Women’s and Children’s Health, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.

17. Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

18. Department of Clinical Haematology, Alfred Health, Melbourne, VIC, Australia.

19. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region.

20. Department of Neurosurgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia.

21. Department of Haematology, Prince of Wales Hospital, Randwick, NSW 2031, Australia.

Abstract

Human adipocytes are a source of tissue-regenerative multipotent stem cells.

Funder

Anthony Rothe Memorial Trust

Australian Research Council

National Health and Medical Research Council

Cancer Institute NSW

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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