Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation-Reference-Cited by-同舟云学术

Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation

Published:2021-03-19 Issue:12 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Mitchell Jane A.¹^ORCID,Shala Fisnik¹,Pires Maria Elisa Lopes¹^ORCID,Loy Rachel Y.¹^ORCID,Ravendren Andrew¹,Benson Joshua¹^ORCID,Urquhart Paula²,Nicolaou Anna²^ORCID,Herschman Harvey R.³,Kirkby Nicholas S.¹^ORCID

Affiliation:

1. Cardio-Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, London, UK.

2. Laboratory for Lipidomics and Lipid Biology, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK.

3. Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.

Abstract

A paradoxical role for vascular COX-1 products in vasoconstriction and atherogenesis highlights it as a novel therapeutic target.

Funder

National Institutes of Health

British Heart Foundation

Phelps Family Foundation

Crump Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary