Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models-Reference-Cited by-同舟云学术

Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models

Author:

Mukherjee Anindit¹^ORCID,MacDonald Kelvin D.¹²^ORCID,Kim Jeonghwan¹^ORCID,Henderson Michael I.³^ORCID,Eygeris Yulia¹^ORCID,Sahay Gaurav¹⁴^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR 97201, USA.

2. Department of Pediatrics, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.

3. Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.

4. Department of Biomedical Engineering, Robertson Life Sciences Building, Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

A nanoparticle delivered ENaC-inhibitory mRNA for the treatment of cystic fibrosis.

Funder

National Institutes of Health

Cystic Fibrosis Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

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