Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice-Reference-Cited by-同舟云学术

Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice

Published:2021-01 Issue:1 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Schneider Nils¹²^ORCID,Wieland Franz-Georg¹³⁴^ORCID,Kong Deqiang⁵,Fischer Alexandra A. M.¹²⁶^ORCID,Hörner Maximilian¹²^ORCID,Timmer Jens¹³,Ye Haifeng⁵^ORCID,Weber Wilfried¹²⁶^ORCID

Affiliation:

1. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.

2. Faculty of Biology, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.

3. Institute of Physics, University of Freiburg, Hermann-Herder-Straße 3, 79104 Freiburg, Germany.

4. Freiburg Center for Data Analysis and Modelling (FDM), University of Freiburg, Ernst-Zermelo-Str. 1, 79104 Freiburg, Germany.

5. Synthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.

6. Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Albertstrasse 21a, 79104 Freiburg, Germany.

Abstract

Engineering liquid-liquid phase separation into synthetic and optogenetic transcription factors increases gene expression.

Funder

Deutsche Forschungsgemeinschaft

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

National Key Laboratory Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary