Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival-Reference-Cited by-同舟云学术

Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival

Published:2020-08-28 Issue:35 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Coronel María M.¹²^ORCID,Martin Karen E.¹²^ORCID,Hunckler Michael D.¹²^ORCID,Barber Graham¹²,O’Neill Eric B.¹²^ORCID,Medina Juan D.²³,Opri Enrico⁴^ORCID,McClain Claire A.²³,Batra Lalit⁵^ORCID,Weaver Jessica D.¹²^ORCID,Lim Hong S.³^ORCID,Qiu Peng³^ORCID,Botchwey Edward A.²³^ORCID,Yolcu Esma S.⁵,Shirwan Haval⁵^ORCID,García Andrés J.¹²^ORCID

Affiliation:

1. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

2. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.

3. Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

4. Department of Neurology, Emory University, Atlanta, GA, USA.

5. Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.

Abstract

Local biomaterial-mediated delivery of PD-L1 induces alloislet graft survival and function in a murine model of type 1 diabetes.

Funder

NIH Office of the Director

JDRF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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