Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5

Author:

Zhou Yu12ORCID,Lei Juan12ORCID,Xie Qichao3ORCID,Wu Lei12ORCID,Jin Shengwei4,Guo Bo5,Wang Xiang12,Yan Guifang12,Zhang Qi12,Zhao Huakan12,Zhang Jiangang12,Zhang Xiao12,Wang Jingchun12,Gu Jiaqi4,Liu Xiaoli6,Ye Duyun7,Miao Hongming8ORCID,Serhan Charles N.9ORCID,Li Yongsheng12ORCID

Affiliation:

1. Clinical Medicine Research Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

2. Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

3. Department of Oncology, Third Affiliated Hospital, Chongqing Medical University, Chongqing 401120, China.

4. Department of Anesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang Province 325027, China.

5. Maternal and Child Health Research Institute, Baoan Women’s and Children’s Hospital, Jinan University, Shenzhen, China.

6. Family Planning Department, Chongqing Health Center for Women and Children, Chongqing 401147, China.

7. Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

8. Department of Biochemistry and Molecular Biology, Third Military Medical University, Chongqing 400038, China.

9. Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Hale Transformative Medicine Building, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Abstract

The dynamic expression of Fgl2 and RvDp5 synergistically programs inflammation resolution to restore homeostasis.

Funder

National Natural Science Foundation of China

NIH R01

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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