Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma-Reference-Cited by-同舟云学术

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

Published:2018-10-05 Issue:10 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Stafford James M.¹²^ORCID,Lee Chul-Hwan¹²^ORCID,Voigt Philipp¹^ORCID,Descostes Nicolas¹²^ORCID,Saldaña-Meyer Ricardo¹²^ORCID,Yu Jia-Ray¹²^ORCID,Leroy Gary¹²,Oksuz Ozgur¹²^ORCID,Chapman Jessica R.³^ORCID,Suarez Fernando⁴⁵^ORCID,Modrek Aram S.⁴⁶^ORCID,Bayin N. Sumru⁴⁶,Placantonakis Dimitris G.⁴⁶⁷⁸^ORCID,Karajannis Matthias A.⁴⁵^ORCID,Snuderl Matija⁴⁹,Ueberheide Beatrix¹³^ORCID,Reinberg Danny¹²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, NYUSoM, New York, NY, USA.

2. Howard Hughes Medical Institute, Chevy Chase, MD, USA.

3. Proteomics Laboratory, NYUSoM, New York, NY, USA.

4. Laura and Isaac Perlmutter Cancer Center, NYUSoM, New York, NY, USA.

5. Department of Pediatrics, NYUSoM, New York, NY, USA.

6. Department of Neurosurgery, NYUSoM, New York, NY, USA.

7. Kimmel Center for Stem Cell Biology, NYUSoM, New York, NY, USA.

8. Neuroscience Institute, NYUSoM, New York, NY, USA.

9. Department of Pathology, Division of Neuropathology, NYUSoM, New York, NY, USA.

Abstract

H3K27M transiently recruits PRC2 to chromatin but persistently affects its activity, leading to an aberrant epigenome in DIPG.

Funder

Howard Hughes Medical Institute

National Institute on Alcohol Abuse and Alcoholism

American Cancer Society

National Cancer Institute

Simons Foundation

Hyundai Hope On Wheels

Making Headway Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference54 articles.

1. Histone variants on the move: substrates for chromatin dynamics

2. Pediatric high-grade glioma: Biologically and clinically in need of new thinking;Jones C.;Neuro Oncol.,2016

3. Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

4. Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

5. EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

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