Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network

Author:

Gao Junjie123ORCID,Qin An4,Liu Delin12,Ruan Rui2ORCID,Wang Qiyang3ORCID,Yuan Jun12ORCID,Cheng Tak Sum2,Filipovska Aleksandra5ORCID,Papadimitriou J. M.26,Dai Kerong4,Jiang Qing7ORCID,Gao Xiang8ORCID,Feng Jian Q.9ORCID,Takayanagi Hiroshi210ORCID,Zhang Changqing3ORCID,Zheng Ming H.12ORCID

Affiliation:

1. Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.

2. Centre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009, Australia.

3. Department of Orthopaedics, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China.

4. Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

5. Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research), University of Western Australia, Nedlands, Western Australia 6009, Australia.

6. Pathwest Laboratory, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.

7. Department of Sports Medicine and Adult Reconstruction Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.

8. State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Collaborative Innovation Center of Genetics and Development, Nanjing University, Nanjing, Jiangsu 210061, China.

9. Department of Biomedical Sciences, Texas A&M College of Dentistry, Dallas, TX 75246, USA.

10. Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.

Abstract

Intercellular mitochondrial transfer mediated by the endoplasmic reticulum is essential for tissue homeostasis.

Funder

National Natural Science Foundation of China

Australian National Health and Medical Research Council (NH&MRC) Project Grant

Early Career Researcher Small Grant from Faculty of Health and Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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