High-speed AFM reveals accelerated binding of agitoxin-2 to a K + channel by induced fit-Reference-Cited by-同舟云学术

High-speed AFM reveals accelerated binding of agitoxin-2 to a K + channel by induced fit

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sumino A.¹²³⁴^ORCID,Sumikama T.¹⁴^ORCID,Uchihashi T.⁵⁶^ORCID,Oiki S.⁴^ORCID

Affiliation:

1. Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa 920-1192, Japan.

2. Institute for Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan.

3. PRESTO, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan.

4. Department of Molecular Physiology and Biophysics, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.

5. Department of Physics and Structural Biology Research Center, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.

6. Exploratory Research Center on Life and Living Systems, National Institute of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.

Abstract

We revealed that binding of agitoxin-2 to a K + channel uses an induced-fit pathway by single-molecule analysis via high-speed AFM.

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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