Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice

Author:

He Hongliang1ORCID,Adili Reheman2ORCID,Liu Lisha1ORCID,Hong Kristen1ORCID,Holinstat Michael23ORCID,Schwendeman Anna14ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, MI 48109, USA.

2. Department of Pharmacology, University of Michigan Medical School, 1150 W. Medical Center Dr., Room 2220D, Medical Sciences Research Building III, Ann Arbor, MI 48109, USA.

3. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, 1150 W. Medical Center Dr., Room 2220D, Medical Sciences Research Building III, Ann Arbor, MI 48109, USA.

4. Biointerfaces Institute, NCRC, 2800 Plymouth Rd., Ann Arbor, MI 48109, USA.

Abstract

sHDL is a promising antithrombotic agent delivery system due to its antithrombotic effect itself and improved drug delivery.

Funder

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

NIH Predoctoral Training Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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