K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

Author:

Lolicato Marco1ORCID,Natale Andrew M.1ORCID,Abderemane-Ali Fayal1,Crottès David2ORCID,Capponi Sara1ORCID,Duman Ramona3,Wagner Armin3ORCID,Rosenberg John M.4ORCID,Grabe Michael15ORCID,Minor Daniel L.16789ORCID

Affiliation:

1. Cardiovascular Research Institute, University of California, San Francisco, CA 93858-2330, USA.

2. Department of Physiology, University of California, San Francisco, CA 93858-2330, USA.

3. Science Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.

4. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USA.

5. Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 93858-2330, USA.

6. Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 93858-2330, USA.

7. California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 93858-2330, USA.

8. Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA, 93858-2330, USA.

9. Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720 USA.

Abstract

The innately heterodimeric K 2P filter permits two C-type gating mechanisms, pinching and dilation, to operate in one channel.

Funder

National Institute of Mental Health

NIH Office of the Director

National Institute of General Medical Sciences

National Institute of Neurological Disorders and Stroke

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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