Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution-Reference-Cited by-同舟云学术

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

Published:2020-07-24 Issue:30 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ukmar-Godec T.¹²^ORCID,Fang P.³^ORCID,Ibáñez de Opakua A.¹^ORCID,Henneberg F.⁴^ORCID,Godec A.⁵^ORCID,Pan K.-T.³^ORCID,Cima-Omori M.-S.¹,Chari A.⁴^ORCID,Mandelkow E.⁶⁷^ORCID,Urlaub H.³⁸,Zweckstetter M.¹²⁹^ORCID

Affiliation:

1. German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 Göttingen, Germany.

2. Department of Neurology, University Medical Center Göttingen, University of Göttingen, Waldweg 33, 37073 Göttingen, Germany.

3. Max Planck Institute for Biophysical Chemistry, Research group Mass Spectrometry, Am Fassberg 11, 37077 Göttingen, Germany.

4. Department for Structural Dynamics, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

5. Mathematical Biophysics Group, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

6. German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Geb. 99, 53127 Bonn, Germany.

7. CAESAR Research Center, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.

8. Bioanalytics, Institute for Clinical Chemistry, University Medical Center, Robert-Koch-Strasse 420, 37075 Göttingen, Germany.

9. Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

Abstract

Dissecting the degradation of the Alzheimer’s disease–related protein Tau by the 20 S proteasome at single-residue resolution.

Funder

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Max Planck Institute for Biophysical Chemistry

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Intrinsically disordered proteins in cellular signalling and regulation

2. Proteolytic processing of tau

3. Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration

4. The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

5. Endoproteolytic Activity of the Proteasome

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