Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species-Reference-Cited by-同舟云学术

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Published:2020-11-06 Issue:45 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kong Hyewon¹^ORCID,Reczek Colleen R.¹,McElroy Gregory S.¹^ORCID,Steinert Elizabeth M.¹^ORCID,Wang Tim²,Sabatini David M.³⁴⁵⁶^ORCID,Chandel Navdeep S.¹^ORCID

Affiliation:

1. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

2. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

3. Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

5. Broad Institute, Cambridge, MA 02142, USA.

6. The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

Mitochondrial complex I inhibition in the presence of a mito-antioxidant induces reductive stress, ISR, and cancer cell death.

Funder

National Institutes of Health

Howard Hughes Medical Institute

American Cancer Society

National Cancer Institute

Cancer Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. The Two Faces of Reactive Oxygen Species in Cancer

2. The Promise and Perils of Antioxidants for Cancer Patients

3. Vitamin E and the Risk of Prostate Cancer

4. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

5. Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

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