Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence-Reference-Cited by-同舟云学术

Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

Published:2019-03 Issue:3 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Dutta Noton K.¹^ORCID,Klinkenberg Lee G.¹^ORCID,Vazquez Maria-Jesus²,Segura-Carro Delfina³^ORCID,Colmenarejo Gonzalo⁴⁵^ORCID,Ramon Fernando⁴^ORCID,Rodriguez-Miquel Beatriz³^ORCID,Mata-Cantero Lydia³,Porras-De Francisco Esther³^ORCID,Chuang Yu-Min¹,Rubin Harvey⁶,Lee Jae Jin⁷^ORCID,Eoh Hyungjin⁷,Bader Joel S.⁸^ORCID,Perez-Herran Esther³,Mendoza-Losana Alfonso³^ORCID,Karakousis Petros C.¹⁹^ORCID

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

2. Medical Department, GlaxoSmithKline, Tres Cantos, Madrid, Spain.

3. Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain.

4. Molecular Discovery Research, GlaxoSmithKline, Tres Cantos, Madrid, Spain.

5. Biostatistics and Bioinformatics Unit, IMDEA Food Institute, Madrid, Spain.

6. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

7. Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, CA, USA.

8. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

9. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Abstract

The stringent response enzyme is a promising new target for Mycobacterium tuberculosis persisters.

Funder

NIAID

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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