DSCAM regulates delamination of neurons in the developing midbrain

Author:

Arimura Nariko1ORCID,Okada Mako12,Taya Shinichiro1,Dewa Ken-ichi12,Tsuzuki Akiko1,Uetake Hirotomo13,Miyashita Satoshi1,Hashizume Koichi1ORCID,Shimaoka Kazumi1ORCID,Egusa Saki1,Nishioka Tomoki4ORCID,Yanagawa Yuchio5,Yamakawa Kazuhiro6,Inoue Yukiko U.1ORCID,Inoue Takayoshi1,Kaibuchi Kozo47,Hoshino Mikio1ORCID

Affiliation:

1. Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

2. Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.

3. Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan.

4. Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.

5. Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Gunma, Japan.

6. Department of Neurodevelopmental Disorder Genetics, Nagoya City University Graduate School of Medicine, Nagoya, Japan.

7. Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.

Abstract

DSCAM regulates neuronal delamination from the ventricular surface by suppressing RapGEF2/Rap1 and N-cadherin.

Funder

Naito Foundation

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Japan Epilepsy Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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