GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Author:

Couto Alves Alexessander12,De Silva N. Maneka G.1,Karhunen Ville1,Sovio Ulla34ORCID,Das Shikta15,Taal H. Rob67,Warrington Nicole M.89ORCID,Lewin Alexandra M.110ORCID,Kaakinen Marika111213ORCID,Cousminer Diana L.141516ORCID,Thiering Elisabeth1718,Timpson Nicholas J.1920ORCID,Bond Tom A.1,Lowry Estelle21ORCID,Brown Christopher D.22ORCID,Estivill Xavier23242526ORCID,Lindi Virpi15,Bradfield Jonathan P.27,Geller Frank28ORCID,Speed Doug2930ORCID,Coin Lachlan J. M.131ORCID,Loh Marie12132ORCID,Barton Sheila J.3334ORCID,Beilin Lawrence J.35,Bisgaard Hans36,Bønnelykke Klaus36,Alili Rohia37ORCID,Hatoum Ida J.373839,Schramm Katharina4041ORCID,Cartwright Rufus142,Charles Marie-Aline43ORCID,Salerno Vincenzo1,Clément Karine3743,Claringbould Annique A. J.44ORCID,van Duijn Cornelia M.45ORCID,Moltchanova Elena46,Eriksson Johan G.474849,Elks Cathy50,Feenstra Bjarke28ORCID,Flexeder Claudia17,Franks Stephen42,Frayling Timothy M.51ORCID,Freathy Rachel M.51ORCID,Elliott Paul15253,Widén Elisabeth16ORCID,Hakonarson Hakon14275455ORCID,Hattersley Andrew T.51,Rodriguez Alina156ORCID,Banterle Marco10,Heinrich Joachim17,Heude Barbara43ORCID,Holloway John W.57ORCID,Hofman Albert645ORCID,Hyppönen Elina585960ORCID,Inskip Hazel3334ORCID,Kaplan Lee M.3839ORCID,Hedman Asa K.6162,Läärä Esa63,Prokisch Holger4041ORCID,Grallert Harald6465,Lakka Timo A.156667ORCID,Lawlor Debbie A.1920,Melbye Mads286869ORCID,Ahluwalia Tarunveer S.36ORCID,Marinelli Marcella252670ORCID,Millwood Iona Y.7172,Palmer Lyle J.73ORCID,Pennell Craig E.8ORCID,Perry John R.50ORCID,Ring Susan M.192074ORCID,Savolainen Markku J.75ORCID,Rivadeneira Fernando4576ORCID,Standl Marie17,Sunyer Jordi24252670ORCID,Tiesler Carla M. T.1718,Uitterlinden Andre G.4576,Schierding William77ORCID,O’Sullivan Justin M.7778ORCID,Prokopenko Inga11136179ORCID,Herzig Karl-Heinz80818283,Smith George Davey1920ORCID,O'Reilly Paul184,Felix Janine F.6745ORCID,Buxton Jessica L.85,Blakemore Alexandra I. F.8687,Ong Ken K.50ORCID,Jaddoe Vincent W. V.645ORCID,Grant Struan F. A.14275455,Sebert Sylvain12180ORCID,McCarthy Mark I.617988ORCID,Järvelin Marjo-Riitta121808286ORCID, ,

Affiliation:

1. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

2. School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.

3. Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.

4. NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

5. MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.

6. The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

7. Department of Paediatrics, Erasmus MC, Sophia Children’s Hospital, Rotterdam, Netherlands.

8. Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

9. The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.

10. Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.

11. Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.

12. Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK

13. Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Surrey, UK.

14. Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA.

15. Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.

16. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

17. Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany.

18. Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany.

19. MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.

20. Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.

21. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.

22. Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

23. Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona, Catalonia, Spain.

24. Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain.

25. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain.

26. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.

27. Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA.

28. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

29. Aarhus Institute of Advanced Studies (AIAS), Aarhus University, Aarhus, Denmark.

30. UCL Genetics Institute, University College London, London, UK.

31. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

32. Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR) Singapore, Singapore.

33. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.

34. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

35. Medical School, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia.

36. COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

37. CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France.

38. Obesity, Metabolism, and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.

39. Department of Medicine, Harvard Medical School, Boston, MA, USA.

40. Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.

41. Institute of Human Genetics, Technische Universität München, München, Germany.

42. Institute for Reproductive and Developmental Biology, Imperial College London, London, UK.

43. Inserm, UMR 1153 (CRESS), Paris Descartes University, Villejuif, Paris, France.

44. University Medical Centre Groningen, Department of Genetics, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.

45. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

46. Department of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand.

47. Department of General Practice and Primary Health Care, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.

48. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.

49. Folkhalsan Research Center, Helsinki, Finland.

50. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

51. Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.

52. National Institute for Health Research, Imperial College Biomedical Research Centre, London, UK.

53. Health Data Research UK London, Imperial College London, London, UK.

54. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

55. Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

56. School of Psychology, College of Social Science, University of Lincoln Brayford Pool Lincoln, Lincolnshire, UK.

57. Human Genetics and Medical Genomics, Faculty of Medicine, University of Southampton, Southampton, UK.

58. South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

59. Great Ormond Street Hospital Institute of Child Health, University College London, London, UK.

60. Australian Centre for Precision Health, University of South Australia Cancer Research Institute, North Terrace, Adelaide, South Australia, Australia.

61. Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

62. Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

63. Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland.

64. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

65. German Center for Diabetes Research (DZD), Neuherberg, Germany.

66. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.

67. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.

68. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

69. Department of Medicine, Stanford University Medical School, Stanford, CA, USA.

70. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.

71. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Old Road Campus, Oxford, UK.

72. Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Oxford, UK.

73. School of Public Health and Robinson Research Institute, University of Adelaide, Adelaide, Australia.

74. Avon Longitudinal Study of Parents and Children, School of Social and Community Medicine, University of Bristol, Bristol, UK.

75. Division of Internal Medicine, and Biocenter of Oulu, Faculty of Medicine, Oulu University, Oulu, Finland.

76. Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

77. Liggins Institute, University of Auckland, Auckland, New Zealand.

78. A Better Start—National Science, Challenge, University of Auckland, Auckland, New Zealand.

79. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK.

80. Biocenter Oulu, University of Oulu, Oulu, Finland.

81. Research Unit of Biomedicine, University Oulu, Oulu, Finland.

82. Medical Research Center and Oulu University Hospital, University of Oulu, Oulu, Finland.

83. Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.

84. MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, De Crespigny Park, London, UK.

85. School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, UK.

86. Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.

87. Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.

88. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.

Abstract

Longitudinal data find a new variant controlling BMI in infancy and reveal genetic differences between infant and adult BMI.

Funder

NIH Office of the Director

Wellcome Trust

Canadian Institutes of Health Research

European Commission

European Research Council

Institut national de la santé et de la recherche médicale

Danish National Research Foundation

Instituto de Salud Carlos III

NIH

NHLBI

Lundbeck Foundation

Academy of Finland

Medical Research Council, UK

Spanish Ministry of Science and Innovation

National Health and Medical Research Council of Australia

Royal Society of New Zealand Marsden Fund

UK Medical Research Council and Wellcome

The European Union’s Horizon 2020 research and innovation programme

Danish Medical Research Council

French Ministry of Research

Biocenter, University of Oulu, Finland

NIH/NIMH

the NIH Genes, Environment and Health Initiative

South West NHS Research and Development

Exeter NHS Research and Development

The Netherlands Organization for Health Research and Development

National Public Health Institute, Helsinki, Finland

Fundació La Marató de TV3, Generalitat de Catalunya

Federal Ministry for Environment IUF Düsseldorf, FKZ

University Hospital Oulu

STAMPEED program

EU Framework Programme 7

UK Biobank Resource

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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