Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1-Reference-Cited by-同舟云学术

Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1

Published:2020-02-21 Issue:8 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Xhani Suela¹^ORCID,Lee Sangchoon¹^ORCID,Kim Hye Mi¹,Wang Siming¹^ORCID,Esaki Shingo¹,Ha Van L. T.¹,Khanezarrin Mahtab¹,Fernandez Giselle L.¹,Albrecht Amanda V.¹,Aramini James M.²,Germann Markus W.¹³^ORCID,Poon Gregory M. K.¹⁴^ORCID

Affiliation:

1. Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

2. Advanced Science Research Center, City University of New York, New York, NY 10031, USA.

3. Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

4. Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

Abstract

Distinct dimeric forms of PU.1 mutually antagonize to control the transcriptionally active dose via a disordered PEST domain.

Funder

National Science Foundation

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. Intrinsic Disorder in Transcription Factors

2. Intrinsic disorder in yeast transcriptional regulatory network

3. Human Transcription Factors Contain a High Fraction of Intrinsically Disordered Regions Essential for Transcriptional Regulation

4. Searching DNA via a “Monkey Bar” Mechanism: The Significance of Disordered Tails

5. C-Terminal Ubiquitination of p53 Contributes to Nuclear Export

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