Cryo-shocked cancer cells for targeted drug delivery and vaccination

Author:

Ci Tianyuan1234ORCID,Li Hongjun1235ORCID,Chen Guojun123,Wang Zejun123ORCID,Wang Jinqiang1235ORCID,Abdou Peter123ORCID,Tu Yiming123,Dotti Gianpietro6ORCID,Gu Zhen12357ORCID

Affiliation:

1. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.

3. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

4. Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China.

5. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.R. China.

6. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Raleigh, NC 27599, USA.

7. Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Liquid nitrogen–treated tumor cells serve as a drug carrier and cancer vaccine to facilitate chemo-immunotherapy.

Funder

National Institutes of Health

University of California, Los Angeles

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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