Structure of TFIIK for phosphorylation of CTD of RNA polymerase II-Reference-Cited by-同舟云学术

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

Published:2021-04-09 Issue:15 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

van Eeuwen Trevor¹²^ORCID,Li Tao³^ORCID,Kim Hee Jong¹²⁴^ORCID,Gorbea Colón Jose J.¹²^ORCID,Parker Mitchell I.⁵⁶^ORCID,Dunbrack Roland L.⁵^ORCID,Garcia Benjamin A.¹⁴,Tsai Kuang-Lei³^ORCID,Murakami Kenji¹^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

4. Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

6. Molecular and Cell Biology and Genetics Program, Drexel University College of Medicine, Philadelphia, PA 19102, USA.

Abstract

Cryo-EM structure of TFIIK provides insight into CTD phosphorylation of RNA polymerase II in the preinitiation-Mediator complex.

Funder

National Science Foundation

National Institutes of Health

National Institute on Aging

NIH Office of the Director

National Cancer Institute

National Institute of General Medical Sciences

Cancer Prevention and Research Institute of Texas