Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection-Reference-Cited by-同舟云学术

Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection

Published:2020-05 Issue:18 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Curley Colleen T.¹^ORCID,Mead Brian P.¹,Negron Karina²³^ORCID,Kim Namho²⁴^ORCID,Garrison William J.¹,Miller G. Wilson¹⁵^ORCID,Kingsmore Kathryn M.¹^ORCID,Thim E. Andrew¹^ORCID,Song Ji¹,Munson Jennifer M.⁶^ORCID,Klibanov Alexander L.¹⁷^ORCID,Suk Jung Soo²³^ORCID,Hanes Justin²³⁴^ORCID,Price Richard J.¹⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.

2. Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

3. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

5. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA.

6. Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.

7. Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

Focused ultrasound is leveraged to markedly augment the delivery of tissue-penetrating gene nanocarriers to brain tumors.

Funder

National Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

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