Transparent arrays of bilayer-nanomesh microelectrodes for simultaneous electrophysiology and two-photon imaging in the brain

Author:

Qiang Yi1,Artoni Pietro2ORCID,Seo Kyung Jin1ORCID,Culaclii Stanislav3ORCID,Hogan Victoria2ORCID,Zhao Xuanyi1,Zhong Yiding1,Han Xun1,Wang Po-Min3,Lo Yi-Kai3,Li Yueming4ORCID,Patel Henil A.5,Huang Yifu6,Sambangi Abhijeet1ORCID,Chu Jung Soo V.1ORCID,Liu Wentai378,Fagiolini Michela2,Fang Hui19ORCID

Affiliation:

1. Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

2. Center for Life Science, Boston Children’s Hospital, Boston, MA 02115, USA.

3. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

4. School of Material Science and Engineering, Tsinghua University, Beijing 100084, China.

5. Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC 27695, USA.

6. School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

7. Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

8. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

9. Department of Bioengineering, Northeastern University, Boston, MA 02120, USA.

Abstract

We report a transparent, bilayer-nanomesh microelectrode array for concurrent electrophysiology recording and two-photon imaging.

Funder

National Institutes of Health

Simons Foundation

University of California, Los Angeles

Northeastern University

RSRT

HFSP-CDF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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4. The Development and Application of Optogenetics

5. Linking Spontaneous Activity of Single Cortical Neurons and the Underlying Functional Architecture

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