Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

Author:

Sarode Poonam1ORCID,Zheng Xiang1ORCID,Giotopoulou Georgia A.2ORCID,Weigert Andreas3ORCID,Kuenne Carste1ORCID,Günther Stefan1ORCID,Friedrich Aleksandra1,Gattenlöhner Stefan4ORCID,Stiewe Thorsten5ORCID,Brüne Bernhard36ORCID,Grimminger Friedrich7ORCID,Stathopoulos Georgios T.2ORCID,Pullamsetti Soni Savai17ORCID,Seeger Werner178ORCID,Savai Rajkumar1678ORCID

Affiliation:

1. Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim 61231, Germany.

2. Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, 26504, Greece and Lung Carcinogenesis Laboratory, Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich 81377, Germany.

3. Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, Frankfurt 60323, Germany.

4. Department of Pathology, Member of the DZL, Justus Liebig University, Giessen 35390, Germany.

5. Institute of Molecular Oncology, Philipps-University Marburg, Member of the DZL, Marburg 35043, Germany.

6. Frankfurt Cancer Institute (FCI), Goethe University, 60596 Frankfurt am Main, Germany.

7. Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392 Giessen, Germany.

8. Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany.

Abstract

Targeting β-catenin–dependent gene regulation in macrophages may offer a new immunotherapeutic option in lung cancer.

Funder

Von-Behring-Röntgen-Stiftung

Max Planck Society

German Center for Lung Research

Rhön Klinikum AG grant

Frankfurt Cancer Institute

Verein zur Förderung der Krebsforschung in Gießen e.V.,

Cardio-Pulmonary Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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