BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation-Reference-Cited by-同舟云学术

BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

Published:2021-05-28 Issue:22 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Vershinin Zlata¹²^ORCID,Feldman Michal¹²,Werner Thilo³^ORCID,Weil Lital Estrella¹²^ORCID,Kublanovsky Margarita¹²^ORCID,Abaev-Schneiderman Elina¹²,Sklarz Menachem²,Lam Enid Y. N.⁴^ORCID,Alasad Khawla²⁵^ORCID,Picaud Sarah⁶^ORCID,Rotblat Barak²⁵^ORCID,McAdam Ruth A.⁷,Chalifa-Caspi Vered²^ORCID,Bantscheff Marcus³^ORCID,Chapman Trevor⁷,Lewis Huw D.⁷,Filippakopoulos Panagis⁶^ORCID,Dawson Mark A.⁴^ORCID,Grandi Paola³^ORCID,Prinjha Rab K.⁷^ORCID,Levy Dan¹²^ORCID

Affiliation:

1. The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, P.O.B. 653, Be’er-Sheva 84105, Israel.

2. National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, P.O.B. 653, Be’er-Sheva 84105, Israel.

3. GSK Cellzome GmbH, Functional Genomics R&D, 69117 Heidelberg, Germany.

4. Sir Peter MacCallum Department of Oncology and Centre for Cancer Research, University of Melbourne, Melbourne, Australia.

5. Department of Life Sciences, Ben-Gurion University of the Negev, Be’er-Sheva 84105, Israel.

6. Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.

7. GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

Abstract

Lysine methylation of BRD4 selectively determines the recruitment of E2F1 to specific target genes to regulate mRNA translation.

Funder

Israel Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

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