HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

Author:

Collier Miranda P.1ORCID,Alderson T. Reid1ORCID,de Villiers Carin P.2,Nicholls Daisy1ORCID,Gastall Heidi Y.1ORCID,Allison Timothy M.13,Degiacomi Matteo T.14ORCID,Jiang He2ORCID,Mlynek Georg5,Fürst Dieter O.6,van der Ven Peter F. M.6,Djinovic-Carugo Kristina57,Baldwin Andrew J.1ORCID,Watkins Hugh2ORCID,Gehmlich Katja28ORCID,Benesch Justin L. P.1ORCID

Affiliation:

1. Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.

2. Division of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Headington, Oxford OX3 9DU, UK.

3. Biomolecular Interaction Centre and School of Physical and Chemical Sciences, University of Canterbury, Christchurch 8140, New Zealand.

4. Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK.

5. Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, A-1030 Vienna, Austria.

6. Department of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, D53121 Bonn, Germany.

7. Department of Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia.

8. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Abstract

The molecular chaperone HspB1 regulates the biomechanical extension of the heart muscle protein filamin C upon stress.

Funder

National Institutes of Health

Wellcome Trust

Pembroke College, University of Oxford

Diamond Light Source

Engineering and Physical Sciences Research Council

British Heart Foundation

Austrian Science Fund

Biotechnology and Biological Sciences Research Council

Oxford University Press

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3