Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

Author:

Carter Stephen D.1ORCID,Hampton Cheri M.2ORCID,Langlois Robert2ORCID,Melero Roberto3ORCID,Farino Zachary J.4,Calderon Michael J.5,Li Wen2,Wallace Callen T.5ORCID,Tran Ngoc Han6ORCID,Grassucci Robert A.2ORCID,Siegmund Stephanie E.78ORCID,Pemberton Joshua9ORCID,Morgenstern Travis J.1011ORCID,Eisenman Leanna12,Aguilar Jenny I.1011ORCID,Greenberg Nili L.1011ORCID,Levy Elana S.1011,Yi Edward1011,Mitchell William G.1011ORCID,Rice William J.13ORCID,Wigge Christoph13,Pilli Jyotsna14ORCID,George Emily W.4,Aslanoglou Despoina4ORCID,Courel Maïté15ORCID,Freyberg Robin J.4,Javitch Jonathan A.1011ORCID,Wills Zachary P.12ORCID,Area-Gomez Estela8,Shiva Sruti141617,Bartolini Francesca18,Volchuk Allen19,Murray Sandra A.5,Aridor Meir5,Fish Kenneth N.4,Walter Peter6ORCID,Balla Tamas9,Fass Deborah20ORCID,Wolf Sharon G.21ORCID,Watkins Simon C.5ORCID,Carazo José María3ORCID,Jensen Grant J.22ORCID,Frank Joachim223,Freyberg Zachary45ORCID

Affiliation:

1. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

2. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

3. Biocomputing Unit, Centro Nacional de Biotecnología–CSIC, Darwin 3, Campus Universidad Autónoma, 28049 Madrid, Spain.

4. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.

5. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

6. HHMI, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

7. Department of Cellular, Molecular and Biophysical Studies, Columbia University Medical Center, New York, NY 10032, USA.

8. Department of Neurology, Columbia University, New York, NY 10032, USA.

9. Section on Molecular Signal Transduction, Program for Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

10. Department of Psychiatry, Columbia University, New York, NY 10032, USA.

11. Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.

12. Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

13. New York Structural Biology Center, New York, NY 10027, USA.

14. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

15. CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre & Marie Curie, 75252 Paris, France.

16. Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

17. Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

18. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

19. Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

20. Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.

21. Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.

22. HHMI, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

23. Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

Abstract

Ribosome-associated vesicles are a novel, dynamic ER-derived organelle.

Funder

National Science Foundation

U.S. Department of Defense

Howard Hughes Medical Institute

Ministerio de Economía y Competitividad

National Institute of General Medical Sciences

National Center for Research Resources

FP7 Ideas: European Research Council

National Institute on Aging

National Institute on Drug Abuse

Pittsburgh Foundation

Leon Levy Foundation

AEI/FEDER

Louis V. Gerstner Jr., Scholars Program

Israel Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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