Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage-Reference-Cited by-同舟云学术

Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage

Published:2024-04-19 Issue:16 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Li Shuo¹^ORCID,Lu Di¹²^ORCID,Li Shupeng³^ORCID,Liu Jiaqi¹^ORCID,Xu Yameng⁴,Yan Ying⁵,Rodriguez Jorge Zárate⁶^ORCID,Bai Hedan¹,Avila Raudel³,Kang Shuming⁷,Ni Xinchen¹^ORCID,Luan Haiwen¹^ORCID,Guo Hexia⁷^ORCID,Bai Wubin⁸^ORCID,Wu Changsheng¹⁹^ORCID,Zhou Xuhao¹⁰^ORCID,Hu Ziying¹^ORCID,Pet Mitchell A.⁶^ORCID,Hammill Chet W.⁶^ORCID,MacEwan Matthew R.⁵^ORCID,Ray Wilson Z.⁵,Huang Yonggang¹³⁷¹¹^ORCID,Rogers John A.¹³⁷¹²¹³^ORCID

Affiliation:

1. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.

2. School of Microelectronics, University of Science and Technology of China, Hefei, Anhui 230026, China.

3. Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

4. The Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

5. Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

7. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

8. Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

9. Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore.

10. Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

11. Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

12. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

13. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Abstract

Continuous monitoring of biomarkers at locations adjacent to targeted internal organs can provide actionable information about postoperative status beyond conventional diagnostic methods. As an example, changes in pH in the intra-abdominal space after gastric surgeries can serve as direct indicators of potentially life-threatening leakage events, in contrast to symptomatic reactions that may delay treatment. Here, we report a bioresorbable, wireless, passive sensor that addresses this clinical need, designed to locally monitor pH for early detection of gastric leakage. A pH-responsive hydrogel serves as a transducer that couples to a mechanically optimized inductor-capacitor circuit for wireless readout. This platform enables real-time monitoring of pH with fast response time (within 1 hour) over a clinically relevant period (up to 7 days) and timely detection of simulated gastric leaks in animal models. These concepts have broad potential applications for temporary sensing of relevant biomarkers during critical risk periods following diverse types of surgeries.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adj0268

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