A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe-Reference-Cited by-同舟云学术

A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

Published:2021-03-19 Issue:12 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Liu Chang¹^ORCID,Gao Jianbo²^ORCID,Cui Xinxin¹^ORCID,Li Zhipeng³^ORCID,Chen Lei¹^ORCID,Yuan Yuan¹,Zhang Yaolei⁴^ORCID,Mei Liangwei²^ORCID,Zhao Lan⁵^ORCID,Cai Dan⁴^ORCID,Hu Mingliang¹^ORCID,Zhou Botong¹^ORCID,Li Zihe¹,Qin Tao¹,Si Huazhe³^ORCID,Li Guangyu³^ORCID,Lin Zeshan¹^ORCID,Xu Yicheng⁶^ORCID,Zhu Chenglong¹,Yin Yuan¹^ORCID,Zhang Chenzhou¹^ORCID,Xu Wenjie¹,Li Qingjie⁷^ORCID,Wang Kun¹^ORCID,Gilbert M. Thomas P.⁸⁹^ORCID,Heller Rasmus¹⁰^ORCID,Wang Wen¹¹¹^ORCID,Huang Jinghui²^ORCID,Qiu Qiang¹^ORCID

Affiliation:

1. School of Ecology and Environment, Northwestern Polytechnical University, Xi’an 710072, China.

2. Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China.

3. College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.

4. BGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.

5. Shaanxi Key Laboratory for Animal Conservation, College of Life Sciences, Xi’an 710069, China.

6. Jiaxing SynBioLab. Co. Ltd., Jiaxing 314000, China.

7. Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China.

8. Center for Evolutionary Hologenomics, GLOBE Institute, University of Copenhagen, Øster Voldgade 5-7, Copenhagen 1350, Denmark.

9. Norwegian University of Science and Technology, University Museum, 7491 Trondheim, Norway.

10. Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen N 2200, Denmark.

11. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.

Abstract

A chromosome-level giraffe genome assembly and gene-edited mice reveal molecular mechanisms underpinning its high stature.

Funder

the National Program for Support of Top-notch Young Professionals

Independent Research Fund Denmark

the Talents Team Construction Fund of Northwestern Polytechnical University

the Research Funds for Interdisciplinary Subject, NWPU

the 1000 Talent Project of Shaanxi Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference76 articles.

1. Winning by a Neck: Tall Giraffes Avoid Competing with Shorter Browsers

2. Scene from above: Retinal ganglion cell topography and spatial resolving power in the giraffe (Giraffa camelopardalis)

3. An allometric analysis of the giraffe cardiovascular system

4. Jugular venous pooling during lowering of the head affects blood pressure of the anesthetized giraffe

5. Sensorimotor responsiveness and resolution in the giraffe

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