Structural basis of broad HIV neutralization by a vaccine-induced cow antibody

Author:

Stanfield Robyn L.123ORCID,Berndsen Zachary T.123,Huang Ruiqi456ORCID,Sok Devin237ORCID,Warner Gabrielle456ORCID,Torres Jonathan L.123ORCID,Burton Dennis R.2378ORCID,Ward Andrew B.123ORCID,Wilson Ian A.1239ORCID,Smider Vaughn V.456ORCID

Affiliation:

1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. IAVI, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

4. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

5. Applied Biomedical Science Institute, San Diego, CA 92127, USA.

6. Taurus Biosciences LLC, San Diego, CA 92127, USA.

7. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

8. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA.

9. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Structure and mutagenesis studies show that a potent vaccine-elicited cow bnAb binds with a compact footprint to HIV gp120 CD4bs.

Funder

National Institutes of Health

Foundation for the National Institutes of Health

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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