Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM-Reference-Cited by-同舟云学术

Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM

Author:

Muñoz-Hernández Hugo¹,Pal Mohinder²,Rodríguez Carlos F.¹,Fernandez-Leiro Rafael¹,Prodromou Chrisostomos²,Pearl Laurence H.²,Llorca Oscar¹^ORCID

Affiliation:

1. Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro 3, 28029 Madrid, Spain.

2. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, UK.

Abstract

Cryo-EM reveals the remodeling of RUVBL1-RUVBL2 ATPases by the client recruitment component in the HSP90 co-chaperone R2TP.

Funder

Wellcome Trust

Spanish Ministry of Science, Innovation and Universities (MCIU/AEI), co-funded by the European Regional Development Fund

Spanish Ministry of Science, Innovation and Universities (MCIU/AEI), co-funded by the European Regional Development Fund (ERDF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

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