A tyrosine sulfation–dependent HLA-I modification identifies memory B cells and plasma cells

Author:

Chan Justin T. H.1ORCID,Liu Yanling1ORCID,Khan Srijit1ORCID,St-Germain Jonathan R.2ORCID,Zou Chunxia3,Leung Leslie Y. T.1ORCID,Yang Judi1,Shi Mengyao1,Grunebaum Eyal4,Campisi Paolo5,Propst Evan J.5,Holler Theresa5,Bar-Or Amit6,Wither Joan E.1,Cairo Christopher W.3ORCID,Moran Michael F.2,Palazzo Alexander F.7ORCID,Cooper Max D.8,Ehrhardt Götz R. A.1ORCID

Affiliation:

1. Department of Immunology, University of Toronto, Toronto, ON, Canada.

2. Department of Molecular Genetics, Hospital for Sick Children, Toronto, ON, Canada.

3. Alberta Glycomics Centre and Department of Chemistry, University of Alberta, Edmonton, AB, Canada.

4. Division of Immunology and Allergy, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

5. Department of Otolaryngology-Head and Neck Surgery, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

6. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

7. Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

8. Department of Pathology and Laboratory Medicine and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

Abstract

We identify a cell type–specific modification of HLA-I using lamprey VLR antibodies as a new class of research reagents.

Funder

National Institutes of Health

Canadian Cancer Society Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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