The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor-Reference-Cited by-同舟云学术

The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor

Published:2020-04-17 Issue:16 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bi Hai-Lian¹^ORCID,Zhang Xiao-Li²^ORCID,Zhang Yun-Long¹,Xie Xin¹^ORCID,Xia Yun-Long¹^ORCID,Du Jie³,Li Hui-Hua¹⁴^ORCID

Affiliation:

1. Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 11600, China.

2. Department of Medical Technology, Beijing Health Vocational College, Beijing 101101, China.

3. Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, Beijing 100029, China.

4. Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Abstract

UCHL1 positively regulates cardiac hypertrophy via stabilizing EGFR and highlighting it as a yet unknown therapeutic target.

Funder

National Natural Science Foundation of China

Chang Jiang Scholar Program of China

Dalian high-level Talents Innovation and Entrepreneurship Projects

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

1. Regulation of cardiac hypertrophy by intracellular signalling pathways