Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α 4 β 7 integrin antibody-Reference-Cited by-同舟云学术

Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α 4 β 7 integrin antibody

Published:2019-01-04 Issue:1 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

He Sijia¹²³^ORCID,Fu Yajing¹²³^ORCID,Guo Jia³,Spear Mark³,Yang Jiuling³,Trinité Benjamin⁴^ORCID,Qin Chaolong¹²⁵,Fu Shuai¹²⁵,Jiang Yongjun¹²⁵,Zhang Zining¹²⁵,Xu Junjie¹²⁵,Ding Haibo¹²⁵,Levy David N.⁴^ORCID,Chen Wanjun⁶,Petricoin Emanuel⁷,Liotta Lance A.⁷,Shang Hong¹²⁵,Wu Yuntao³^ORCID

Affiliation:

1. Key Laboratory of AIDS Immunology of National Health Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P. R. China.

2. Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, Liaoning 110001, P. R. China.

3. National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.

4. Department of Basic Science, New York University College of Dentistry, New York, NY 10010, USA.

5. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, P. R. China.

6. Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD 20892, USA.

7. Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.

Abstract

We demonstrate an HIV-mediated dysregulation of cofilin in CD4 T cells and propose therapeutics to restore T cell motility.

Funder

U.S. Department of Health and Human Services

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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