Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens-Reference-Cited by-同舟云学术

Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens

Published:2021-07-02 Issue:27 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lopes Rui¹^ORCID,Sprouffske Kathleen¹^ORCID,Sheng Caibin¹^ORCID,Uijttewaal Esther C. H.¹^ORCID,Wesdorp Adriana Emma¹^ORCID,Dahinden Jan¹,Wengert Simon¹^ORCID,Diaz-Miyar Juan¹,Yildiz Umut¹^ORCID,Bleu Melusine¹,Apfel Verena¹,Mermet-Meillon Fanny¹,Krese Rok¹,Eder Mathias¹,Olsen André Vidas²^ORCID,Hoppe Philipp³,Knehr Judith³,Carbone Walter³^ORCID,Cuttat Rachel³^ORCID,Waldt Annick³^ORCID,Altorfer Marc³,Naumann Ulrike³^ORCID,Weischenfeldt Joachim²,deWeck Antoine¹^ORCID,Kauffmann Audrey¹,Roma Guglielmo³^ORCID,Schübeler Dirk⁴⁵^ORCID,Galli Giorgio G.¹^ORCID

Affiliation:

1. Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland.

2. Biotech Research and Innovation Centre (BRIC), The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

3. Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland.

4. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

5. Faculty of Sciences, University of Basel, Basel, Switzerland.

Abstract

Combination of functional epigenomics and single-cell CRISPR screens reveals that ER exerts its oncogenic role via downstream TFs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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