Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations-Reference-Cited by-同舟云学术

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

Published:2018-03-02 Issue:3 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Huang Hui¹²^ORCID,Kuenze Georg²³⁴^ORCID,Smith Jarrod A.¹²^ORCID,Taylor Keenan C.¹²^ORCID,Duran Amanda M.²³⁴^ORCID,Hadziselimovic Arina¹²^ORCID,Meiler Jens²³⁴⁵,Vanoye Carlos G.⁶,George Alfred L.⁶,Sanders Charles R.¹²⁷^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, USA.

2. Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.

3. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.

4. Department of Pharmacology, Vanderbilt University, Nashville, TN 37240, USA.

5. Department of Bioinformatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

6. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

7. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

Long QT syndrome–associated mutations in KCNQ1 most often destabilize the protein, leading to mistrafficking and degradation.

Funder

National Science Foundation

National Institutes of Health

German Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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