A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans-Reference-Cited by-同舟云学术

A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans

Published:2022-01-07 Issue:1 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Coppo Lucia¹^ORCID,Mishra Pradeep¹^ORCID,Siefert Nora¹^ORCID,Holmgren Arne¹,Pääbo Svante²³^ORCID,Zeberg Hugo²⁴^ORCID

Affiliation:

1. Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17165 Stockholm, Sweden.

2. Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.

3. Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan.

4. Department of Neuroscience, Karolinska Institutet, SE-17165 Stockholm, Sweden.

Abstract

In contrast to archaic humans such as Neanderthals, modern humans have a more efficient enzyme for combating oxidative stress.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

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3. GLUTATHIONE REDUCTASE ACTIVITY IN BLOOD AND BODY FLUIDS1

4. Rapid Induction of Cell Death by Selenium-compromised Thioredoxin Reductase 1 but Not by the Fully Active Enzyme Containing Selenocysteine

5. The complete genome sequence of a Neanderthal from the Altai Mountains

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