Nanocapsules modify membrane interaction of polymyxin B to enable safe systemic therapy of Gram-negative sepsis-Reference-Cited by-同舟云学术

Nanocapsules modify membrane interaction of polymyxin B to enable safe systemic therapy of Gram-negative sepsis

Published:2021-08-06 Issue:32 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yuk Simseok A.¹^ORCID,Kim Hyungjun¹²^ORCID,Abutaleb Nader S.³⁴^ORCID,Dieterly Alexandra M.³,Taha Maie S.¹⁵^ORCID,Tsifansky Michael D.⁶,Lyle L. Tiffany³^ORCID,Seleem Mohamed N.³⁴^ORCID,Yeo Yoon¹⁷^ORCID

Affiliation:

1. Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.

2. Department of Applied Chemistry, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, Gyeongbuk 39177, Republic of Korea.

3. Department of Comparative Pathobiology, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USA.

4. Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, 1410 Prices Fork Road, Blacksburg, VA 24061, USA.

5. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

6. Pediatric Cardiac Critical Care Medicine and Pediatric Pulmonology, Children’s National Medical Center, Michigan Ave NW, Washington, DC 20310, USA.

7. Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Dr., West Lafayette, IN 47907, USA.

Abstract

Nanocapsules modify membrane interaction of polymyxin B to reduce its toxicity and enable safe systemic therapy of sepsis.

Funder

National Institutes of Health

Purdue University Institute for Drug Discovery

Graduate Assistance in Areas of National Need Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference75 articles.

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2. Sepsis incidence and outcome: Contrasting the intensive care unit with the hospital ward*

3. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

4. C. M. Torio B. J. Moore in Healthcare Cost and Utilization Project (HCUP) Statistical Briefs (Agency for Healthcare Research and Quality (US) 2016).

5. The immunopathology of sepsis and potential therapeutic targets

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