A highly conserved 3 10 helix within the kinesin motor domain is critical for kinesin function and human health-Reference-Cited by-同舟云学术

A highly conserved 3 10 helix within the kinesin motor domain is critical for kinesin function and human health

Published:2021-04-30 Issue:18 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lam Aileen J.¹^ORCID,Rao Lu²^ORCID,Anazawa Yuzu³⁴,Okada Kyoko¹,Chiba Kyoko¹⁴,Dacy Mariah¹,Niwa Shinsuke⁴,Gennerich Arne²^ORCID,Nowakowski Dan W.⁵^ORCID,McKenney Richard J.¹^ORCID

Affiliation:

1. Department of Molecular and Cellular Biology, University of California, Davis. Davis, CA 95616, USA.

2. Department of Anatomy and Structural Biology and Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

3. Department of Biology, Faculty of Science, Tohoku University, Sendai, 980-8578 Miyagi, Japan.

4. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, 980-0845 Miyagi, Japan.

5. N Molecular Systems Inc., Palo Alto, CA 94303, USA.

Abstract

An uncharacterized structural element in the kinesin motor domain is shown to be critical for motor function and human health.

Funder

National Institutes of Health

the Japan Society for the Promotion of Science

JSPS Overseas Research Fellowship

Hayaishi Memorial Scholarship for Study Abroad

KIF1A.org

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Kinesin superfamily motor proteins and intracellular transport

2. The neuron-specific kinesin superfamily protein KIF1A is a uniqye monomeric motor for anterograde axonal transport of synaptic vesicle precursors

3. The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors

4. Dimerization of mammalian kinesin-3 motors results in superprocessive motion

5. Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

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