Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer-Reference-Cited by-同舟云学术

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

Published:2021-10-08 Issue:41 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Loo Ser Yue¹^ORCID,Toh Li Ping¹²,Xie William Haowei¹^ORCID,Pathak Elina¹,Tan Wilson¹,Ma Siming¹^ORCID,Lee May Yin¹^ORCID,Shatishwaran S.¹^ORCID,Yeo Joanna Zhen Zhen¹³,Yuan Ju¹,Ho Yin Ying⁴,Peh Esther Kai Lay⁴^ORCID,Muniandy Magendran⁵,Torta Federico²⁵⁶,Chan Jack⁷^ORCID,Tan Tira J.⁷⁸^ORCID,Sim Yirong⁹^ORCID,Tan Veronique⁹^ORCID,Tan Benita⁹^ORCID,Madhukumar Preetha⁹,Yong Wei Sean⁹,Ong Kong Wee⁹,Wong Chow Yin⁹,Tan Puay Hoon¹⁰^ORCID,Yap Yoon Sim⁷⁸^ORCID,Deng Lih-Wen²^ORCID,Dent Rebecca⁷^ORCID,Foo Roger¹^ORCID,Wenk Markus R.²⁵⁶^ORCID,Lee Soo Chin¹¹¹²^ORCID,Ho Ying Swan⁴^ORCID,Lim Elaine Hsuen⁷^ORCID,Tam Wai Leong¹²³¹²¹³^ORCID

Affiliation:

1. Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Singapore 138672, Singapore.

2. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.

3. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

4. Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Singapore 138668, Singapore.

5. Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.

6. Precision Medicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.

7. Division of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore 169610, Singapore.

8. Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.

9. Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore 169610, Singapore.

10. Division of Pathology, Singapore General Hospital, 20 College Rd., Singapore 169856, Singapore.

11. Department of Haematology-Oncology, National University Cancer Institute, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.

12. Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.

13. NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University Singapore, 14 Medical Drive, Singapore 117599, Singapore.

Abstract

Fatty acid oxidation is a metabolic gateway that regulates cellular plasticity and supports metastasis in breast cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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