Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R +/− mouse model of ALSP, which can be rescued via CSF1R inhibitors-Reference-Cited by-同舟云学术

Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R +/− mouse model of ALSP, which can be rescued via CSF1R inhibitors

Published:2021-08-27 Issue:35 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Arreola Miguel A.¹^ORCID,Soni Neelakshi¹^ORCID,Crapser Joshua D.¹,Hohsfield Lindsay A.¹,Elmore Monica R. P.¹,Matheos Dina P.¹^ORCID,Wood Marcelo A.¹^ORCID,Swarup Vivek¹^ORCID,Mortazavi Ali²^ORCID,Green Kim N.¹^ORCID

Affiliation:

1. Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.

2. Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.

Abstract

Microglia dyshomeostasis induces pathology in CSF1R +/− mice, which can be reduced with pharmacological CSF1R inhibition.

Funder

National Institutes of Health

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Alzheimer’s Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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