Wireless, battery-free push-pull microsystem for membrane-free neurochemical sampling in freely moving animals

Author:

Wu Guangfu1ORCID,Heck Ian2,Zhang Nannan3,Phaup Glenn4ORCID,Zhang Xincheng1,Wu Yixin5ORCID,Stalla David E.6,Weng Zhengyan1,Sun He1,Li Huijie1ORCID,Zhang Zhe23,Ding Shinghua23,Li De-Pei4,Zhang Yi1ORCID

Affiliation:

1. Department of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.

2. Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211, USA.

3. Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA.

4. Center for Precision Medicine, University of Missouri, Columbia, MO 65212, USA.

5. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

6. Electron Microscopy Core, University of Missouri, Columbia, MO 65211, USA.

Abstract

Extensive studies in both animals and humans have demonstrated that high molecular weight neurochemicals, such as neuropeptides and other polypeptide neurochemicals, play critical roles in various neurological disorders. Despite many attempts, existing methods are constrained by detecting neuropeptide release in small animal models during behavior tasks, which leaves the molecular mechanisms underlying many neurological and psychological disorders unresolved. Here, we report a wireless, programmable push-pull microsystem for membrane-free neurochemical sampling with cellular spatial resolution in freely moving animals. In vitro studies demonstrate the sampling of various neurochemicals with high recovery (>80%). Open-field tests reveal that the device implantation does not affect the natural behavior of mice. The probe successfully captures the pharmacologically evoked release of neuropeptide Y in freely moving mice. This wireless push-pull microsystem creates opportunities for neuroscientists to understand where, when, and how the release of neuropeptides modulates diverse behavioral outputs of the brain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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