Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development

Author:

Zaksauskaite Ringaile1ORCID,Thomas Ruth C12ORCID,van Eeden Freek12ORCID,El-Khamisy Sherif F.13ORCID

Affiliation:

1. Healthy Lifespan Institute, Sheffield Institute for Neuroscience, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.

2. Bateson Centre, Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, UK.

3. The Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.

Abstract

The repair of protein-linked chromosomal breaks requires distinct factors throughout the life span.

Funder

Wellcome

Biotechnology and Biological Sciences Research Council

Rosetrees Trust

Lister Institute of Preventive Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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