MLL4 mediates differentiation and tumor suppression through ferroptosis-Reference-Cited by-同舟云学术

MLL4 mediates differentiation and tumor suppression through ferroptosis

Published:2021-12-10 Issue:50 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Egolf Shaun¹²^ORCID,Zou Jonathan¹²^ORCID,Anderson Amy¹²^ORCID,Simpson Cory L.¹^ORCID,Aubert Yann¹²^ORCID,Prouty Stephen¹^ORCID,Ge Kai³^ORCID,Seykora John T.¹⁴^ORCID,Capell Brian C.¹²⁴⁵⁶^ORCID

Affiliation:

1. Department of Dermatology, University of Pennsylvania Perelman School of Medicine Philadelphia, PA 19104, USA.

2. Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

3. National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

5. Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

6. Penn Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Abstract

This study reveals how epigenetic errors drive skin cancer initiation via altered cell fate and impaired ferroptosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

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3. Human gene essentiality

4. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

5. COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer

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